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The disease has a biphasic distribution, most frequently affecting teens/young adults and individuals beyond the age of 60 years. 50% of patients with aplastic anaemia have small PNH clones. The molecular pathogenesis of AA is not fully understood, and a uniform process may not be the culprit across all cases. 1.1.2. Aplastic Anemia (AA), a type of bone marrow failure syndromes, is an uncommon hematological disorder with immune pathophysiology. Regardless of this, pathogenesis of Aplastic Anemia is immune mediated, and is determined by cytotoxic action of T-lymphocytes against the hematopoietic stem cells, which eventually dieby apoptosis. His physician attributed the patient’s jaundice and paleness to BMT reaction. Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). 1,068. Fanconi anemia is the most common hereditary cause. Hepatitis-associated aplastic anemia (HAAA) is a variant of severe aplastic anemia (SAA) in which bone marrow failure follows an acute attack of hepatitis. We present 3 cases of hepatitis-associated aplastic anemia after hepatitis A virus infection. Rarely the disease follows an episode of self-limiting, sero-negative hepatitis. Hepatitis-associated aplastic anemia (HAAA) is a variant of acquired aplastic anemia in which bone marrow failure follows the development of an acute episode of seronegative hepatitis. In this latter case the diagnosis of hepatitis- Results. Aplastic anemia developed in 9 of 32 patients (28 percent) undergoing orthotopic liver transplantation for acute non-A, non-B hepatitis, at one to seven weeks after the procedure. Objectives: Hepatitis-associated aplastic anemia (HAA) is a rare variant of aplastic anemia in which patients present with severe pancytopenia after an episode of acute hepatitis.The marrow failure is often rapid, severe, and usually fatal if untreated. Hepatitis-associated aplastic anemia (HAAA) is an uncommon but distinct variant of aplastic anemia in which pancytopenia appears two to three months after an acute attack of hepatitis. Blood cells are produced in the bone marrow by stem cells that reside there. The etiology of this syndrome is proposed to be attributed to various hepatitis and non hepatitis viruses. From 1988 to 2010, 38 children were included under the following criteria: negative virological studies, no serum autoantibodies, exclusion of other causes of liver diseases, and liver histology compatible with autoimmune hepatitis. All 3 patients were male individuals under the age of 20. 2B). Other types of Normocytic-Normochromic Anemias besides Aplastic Anemia. Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections). Sometimes, a reduced peripheral blood cells count may be found during tests per-formed for another reason or as a screening. Background HAA is a sequence of seronegative hepatitis … 5-10% of severe acquired cases of aplastic anemia are preceded by seronegative hepatitis. To describe features, management and outcome of childhood seronegative autoimmune hepatitis. Patients generally are diagnosed with MDS around the time of symptomatic AD. We present the case of a 16-month-old Japanese male who developed HAAA following living- donor liver transplantation for fulminant hepatitis. 9. All three patients experienced remission of their disease at the time of the occurrence of marrow aplasia. Several hepatitis viruses have been linked to the disease, but in many cases no … Three patients receiving gold salt treatment for rheumatoid arthritis devel oped severe aplastic anemia. 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